![]() One of the pathways, 4-OH to estrogen detoxification can lead to a lot of inflammation. Through phase I of detoxification there are two pathways estrogen can go down. As a response, you feel a lot of swelling and flare-ups of pain that contribute to the cramps you feel in endometriosis. In the case of endometriosis, the foreign uterine tissue that implants in the pelvic region causes inflammation to occur because the body knows that this tissue doesn’t belong. Inflammation occurs when your white blood cells sense an invader or an area of injury in the body, so they release chemicals to surge the area as well as increase blood flow there. Reducing inflammation is another benefit of DIM for endometriosis. DIM for endometriosis helps lower elevated levels of estrogen because it helps to reduce this free estrogen by promoting detoxification. The tissues in the endometriosis have many estrogen beta receptors which cause an increase in estrogen circulation. This is because elevated levels of estrogen cause a large impact on endometriosis. ![]() Lower levels of estrogen is another one of the benefits of DIM for endometriosis. Source: Oregon State, Estrogen Metabolism DIM supports this phase and allows this to occur and for estrogen to be excreted instead of recirculated. Again, too much estrogen can elevate your levels and cause an increase in endometrial pain. There are 3 main steps that occur, and all of them need to take place in order for it to excrete the estrogen. There are 2 main phases of estrogen excretion, and DIM favors phase I which is detoxification. ![]() Support Phase 1 Estrogen DetoxificationĪnother reason DIM for endometriosis works is because it supports phase 1 of estrogen detoxification. It can reduce estrogen which will decrease the intensity of the prostaglandins.ģ. DIM can aid in this because of its role in estrogen detoxification. This is why painful periods are one of the signs of high estrogen. Prostaglandins in the reproductive system aid in contractions for labor, but when you are not in labor these contractions are labeled as cramps. Prostaglandins are sex hormones that work in parallel with estrogen, so when estrogen increases right before menstruation, then prostaglandin will increase. The cramps in the uterus can be caused by high amplitude contractions, increased uterine tone, and high levels of prostaglandins. Painful periods or dysmenorrhea is noted as painful cramps during menstruation. Reducing period pain is another reason DIM for endometriosis is beneficial. This is why reducing heavy bleeding is a benefit of DIM for endometriosis because it aids in estrogen detoxification, which will lower the amount of estrogen and therefore reduce heavy bleeding. Estrogen functions to build up the endometrial wall for menstruation, so heavy menstrual bleeding is caused by the increase in estrogen. Heavy bleeding is caused by polyps which are when there is enlarged tissue growth in the endometrial cavity. The normal bleeding amount is only 50-60 mL of blood. Heavy menstrual bleeding is defined as secreting more than 80 mL of blood per menstrual cycle, though it is reported that about 50% of females who report heavy menstrual bleeding, do not meet the 80 mL standard. Heavy bleeding is a sign of high estrogen. Here are 5 benefits of DIM for endometriosis: 1. It helps with endometriosis because it lowers total estrogen and improves estrogen detoxification. DIM has been shown to be one of the supplements for endometriosis to relieve some pain. The goal of endometriosis is to reduce pain and inflammation because there is no cure.ĭIM stands for diindolylmethane and it is a naturally occurring compound in cruciferous vegetables like broccoli, kale, and cauliflower. Digestive issues are another problem with endometriosis because of a failure to eliminate excess estrogen. The condition is associated with estrogen dominance because the tissues in endometriosis often contain many estrogen receptors on them.
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